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℡ 4000-520-616
℡ 4000-520-616
tecomedical/Calcium metabolism/25 µl/60-2700
产品编号:60-2700
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 仪器类>组织处理>烘片机>
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品      牌: tecomedical
公      司:tecomedical
公司分类:
tecomedical/Calcium metabolism/25 µl/60-2700
商品介绍

Calcium metabolism

Product name

PTH 1-84 Bioactive, Rat

Cat-Nr.60-2700
Range25 – 840 pg/ml (can be extended to 2700 pg/ml)
Sensitivity3 pg/ml
Incubation time3.5 hours
Sample volume25 µl
Sample type

EDTA plasma, cell culture

Sample preparation

Samples should be tested immediately or stored frozen at-20°C or below.

Species

Rat, mouse

Standards

Synthetic rat PTH 1-84

Specificity

Antibodies directed against C- and N-terminal epitope. Detect only bioactive intact rat PTH.

Tests96 Tests
MethodELISA
Intended use

PTH (Parathyroid hormone, Parathormone, Parathyrin) is biosynthesized in the parathyroid gland as a preproparathyroid hormone, a larger molecular precursor consisting of 115 amino acids. Following sequential intracellular cleavage of a 25-amino acid sequence, pre-proparathyroid hormone is converted to an intermediate, a 90-amino acid polypeptide, proparathyroid hormone. By additional proteolytic modification, proparathyroid hormone is then converted to parathyroid hormone, an 84 amino acid polypeptide. In healthy individuals, regulation of parathyroid hormone secretion normally occurs via a negative feedback action of serum calcium on the parathyroid glands. Intact PTH is biologically active and clears very rapidly from the circulation with a half-life of less than four minutes. PTH undergoes proteolysis in the parathyroid glands, but mostly peripherally, particularly in the liver but also in the kidneys and bone, to give N-terminal fragments and longer lived C-terminal and Mid-region fragments. Intact PTH assays are important for the differentiation of primary hyperparathyroidism from other (non-parathyroid-mediated) forms of hypercalcemia, such as cancer, sarcoidosis and thyrotoxicosis.

Product informations
Kit Instructions (PDF 284,3 kB)
Cross-reaction all species (PDF 74,6 kB)
Bone & Cartilage Metabolism (PDF 1,8 MB)

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品牌介绍

tecomedical总部位于瑞士的TECOmedical Group在德国,法国和比荷卢三国设有子公司,是医学和兽医诊断,生物安全和环境测试领域体外专业测试系统的领先提供商。此外,我们与意见领袖合作开发或评估新的测试系统,或为制药,CRO和研究组织提供服务。

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