Cartilage metabolism

Product name	CP II / PIICP Collagen synthesis C-terminal Propeptide of Collagen Type-II (PIICP)
Cat-Nr.	60-1003-001
Range	50 - 2000 ng/ml
Incubation time	4 hours
Sample volume	25 μl (dilute 1:2)
Sample type	Serum (also used for cell culture, synovial fluid, cartilage extract)
Sample preparation	Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples. Serum: stable > 1 year at -70 °C.
Species	Human (also used for horse, bovine, dog, mouse, rat, rhesus macaque, sheep, guinea pig). The use of rabbit samples may lead to high background interference.
Tests	96 Tests
Method	ELISA
Intended use	CP-II as a biomarker is used in the investigation of the cartilage synthesis in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and cartilage injury and repair in human as well as some animal models. The CP-II-concentration in cartilage correlates directly with the synthesis of the type-II collagen.
Product informations	Kit Instructions (PDF 100,0 kB) Cross-reaction all species (PDF 74,6 kB) Bone & Cartilage Metabolism (PDF 1,8 MB) Cartilage Monograph (PDF 2,0 MB) Information: OA Biomarkers (PDF 234,6 kB) Information: RA Biomarkers (PDF 328,6 kB) (PDF 2,0 MB)