Cartilage metabolism

Chondroitin Sulfate 846 Epitope of Proteoglycan Aggrecan

Serum (also used for synovial fluid, cell culture, cartilage extract)

Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples. Serum: stable > 1 year at -70 °C.

Human (also used for horse, bovine, dog, rabbit, guinea pig, rat, rhesus macaque, sheep). The use of mouse samples may lead to high background interference.

Chondroitin sulfate, dermatan sulphate and keratan sulfate alone, either in their native or degraded state, show no reactivity.

CS-846, a chondroitin sulfate epitope, which is normally only present on intact aggrecan “fetal-like” proteoglycan, is used as a biomarker in the investigation of the cartilage synthesis/turnover in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and cartilage injury and repair in human as well as some animal models.