Growth metabolism
| Product name | IGFBP-2 Mouse / RatInsulin like Growth Factor Binding Protein-2 for mouse and rat | |||||||||
| Cat-Nr. | E08 | |||||||||
| Range | 31 – 2000 pg/ml (after dilution 1:100) | |||||||||
| Sensitivity | 0.01 ng/ml | |||||||||
| Incubation time | 3 hours RT | |||||||||
| Sample volume | 10 µl (dilute 1:100) | |||||||||
| Sample type | Serum | |||||||||
| Sample preparation | Samples have to be chilled as soon as possible after collection. Long-term storage should be carried out at –20°C or below. Avoid repeated freezing/thawing of specimens. | |||||||||
| Reference values |
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| Species | mouse, rat | |||||||||
| Tests | 96 Tests | |||||||||
| Method | ELISA | |||||||||
| Intended use | IGFBP-2 is an unglycosylated polypeptide of 31.3 kDa, which forms binary IGF-complexes and shows no circadian rhythm in the circulation. The serum concentration of IGFBP-2 increases in fasting, after major surgery and after trauma, but the increasing of the concentration is most intensive in malignant diseases. The correlation of the IGFBP-2 level to the degree of progression is a striking feature in various tumor types as is the normalization of the IGFBP-serum levels after remission. During the GH-therapy, e.g. in short stature and in GH-abuse (doping) the IGFBP-2 level decreases. In Trisomy 18 IGFBP-2 in maternal serum is decreased and IGFBP-1 is increased; therefore the ratio IGFBP-2/IGFBP-1 is a marker for this chromosome abnormality. Especially in tumor biology the mouse and rat systems enable investigation of the systemic relevance of IGFBP-2. IGFBP-2 influences tumor cells as it induces catalase activity in adrenocortical cells. Furthermore IGFBP-2 interacts with tumor cells via its RGD-amino acid sequence and seems to stimulate cell invasion of glioma cells. | |||||||||
| Product informations | Kit Instructions (PDF 638,6 kB) Cross-reaction all species (PDF 74,6 kB) |
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tecomedical总部位于瑞士的TECOmedical Group在德国，法国和比荷卢三国设有子公司，是医学和兽医诊断，生物安全和环境测试领域体外专业测试系统的领先提供商。此外，我们与意见领袖合作开发或评估新的测试系统，或为制药，CRO和研究组织提供服务。
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